PDA

View Full Version : Science: Genetic-based pharmaceuticals?



Gerry Clinchy
11-14-2011, 07:14 AM
Saw an amazing documentary on the Science channel yesterday.

A geneticist was fascinated by the fact that there were people that had survived both the bubonic and pneumonic plagues in Europe in the 14th & 17th centuries. He also noted that there were more survivors in the 17th century epidemic. The researcher had been motivated by losing his brother to HIV.

He had begun studying a more recent hemophiliac who had was HIV positive, but never developed AIDS. Found that this hemophiliac had 2 copies of a gene that he named "Delta 32".

This gene had the effect of causing the cell "portals" that HIV used to invade cells, to be blocked; so that the HIV virus could not enter the cells.

Pharmaceuticals were developed that duplicated the effect of Delta 32. They interviewed a test subject from the early research with HIV who has survived 20 years now, and whose response to the therapy (of duplicating effects of Delta 32) was "miraculously" rapid.

He then went to Europe to take samples from people who could trace their ancestry directly back to survivors of the epidemic of the 17th century. A small town in England that was "invaded" by the plague virus by a travelling salesman, and decided to "quarantine" itself. The Delta 32 gene was also found in this population.

He believes that this genetic research may lead to a new approach to pharmaceuticals to treat many diseases: not killing the offensive organism, but preventing the organism from invading the cells.

It was not mentioned whether the research was govt-funded or private-sector-funded.

charly_t
11-14-2011, 12:48 PM
Saw an amazing documentary on the Science channel yesterday.

A geneticist was fascinated by the fact that there were people that had survived both the bubonic and pneumonic plagues in Europe in the 14th & 17th centuries. He also noted that there were more survivors in the 17th century epidemic. The researcher had been motivated by losing his brother to HIV.

He had begun studying a more recent hemophiliac who had was HIV positive, but never developed AIDS. Found that this hemophiliac had 2 copies of a gene that he named "Delta 32".

This gene had the effect of causing the cell "portals" that HIV used to invade cells, to be blocked; so that the HIV virus could not enter the cells.

Pharmaceuticals were developed that duplicated the effect of Delta 32. They interviewed a test subject from the early research with HIV who has survived 20 years now, and whose response to the therapy (of duplicating effects of Delta 32) was "miraculously" rapid.

He then went to Europe to take samples from people who could trace their ancestry directly back to survivors of the epidemic of the 17th century. A small town in England that was "invaded" by the plague virus by a travelling salesman, and decided to "quarantine" itself. The Delta 32 gene was also found in this population.

He believes that this genetic research may lead to a new approach to pharmaceuticals to treat many diseases: not killing the offensive organism, but preventing the organism from invading the cells.

It was not mentioned whether the research was govt-funded or private-sector-funded.

I had not heard about this. I copied it for more study and to share with my sister ( who does not have a computer and she will find this very interesting ). Maybe she has already read about it but just in case I'm going to print it for her.

BonMallari
11-14-2011, 01:46 PM
the amount of new age drugs,treatments and machines that are currently bogged down in the FDA approval line is mind boggling...federal bureaucracy at its worst...not saying that the next cure for cancer and other maladies isnt already out there, but if they would loosen up the red tape, many more people could be helped and possibly saved

road kill
11-14-2011, 01:49 PM
Saw an amazing documentary on the Science channel yesterday.

A geneticist was fascinated by the fact that there were people that had survived both the bubonic and pneumonic plagues in Europe in the 14th & 17th centuries. He also noted that there were more survivors in the 17th century epidemic. The researcher had been motivated by losing his brother to HIV.

He had begun studying a more recent hemophiliac who had was HIV positive, but never developed AIDS. Found that this hemophiliac had 2 copies of a gene that he named "Delta 32".

This gene had the effect of causing the cell "portals" that HIV used to invade cells, to be blocked; so that the HIV virus could not enter the cells.

Pharmaceuticals were developed that duplicated the effect of Delta 32. They interviewed a test subject from the early research with HIV who has survived 20 years now, and whose response to the therapy (of duplicating effects of Delta 32) was "miraculously" rapid.

He then went to Europe to take samples from people who could trace their ancestry directly back to survivors of the epidemic of the 17th century. A small town in England that was "invaded" by the plague virus by a travelling salesman, and decided to "quarantine" itself. The Delta 32 gene was also found in this population.

He believes that this genetic research may lead to a new approach to pharmaceuticals to treat many diseases: not killing the offensive organism, but preventing the organism from invading the cells.

It was not mentioned whether the research was govt-funded or private-sector-funded.

I met someonme from Harris-Stowe College in St. Louis MO.
(adjacent to St. Louis University)
We discussed this at length.
NASA developed a process for this a few years ago.
It allows "pharmaceuticals" to bond with your dna.
The process is now commercial.

PED's are now linked to ones dna and can NOT be detected using this same process.


This young man listed the names of those who came to use this process.
Ironically, several proved to be true.

NBot to hijack your thread, but the upside of this is HUGE!!!


RK

Gerry Clinchy
11-14-2011, 03:21 PM
Stan what does PED stand for?

The researcher did, indeed, mention the possibilities for other diseases, like various cancers, and other chronic diseases. Delta 32 happens to be associated with at least these two infectious diseases, but there could be other similar mutations that act upon other infectious disease; and there may be other mutations that are associated with other types of chronic diseases. He mentioned both prostate and breast cancers.

HUGE is not an exaggeration. And look at the ramifications ... if lifespans are extended, the fiscal impact will be one impact. Medicare may avoid large expenses by keeping people healthier, but SS would have to deal with people livingmore years; and pension plans; and welfare programs as well. If the Chinese live longer, their population growth will be hard to control.

BonMallari
11-14-2011, 03:38 PM
PED = performance enhancing drugs...aka steroids, HGH, human growth hormone

road kill
11-14-2011, 04:25 PM
Stan what does PED stand for?

The researcher did, indeed, mention the possibilities for other diseases, like various cancers, and other chronic diseases. Delta 32 happens to be associated with at least these two infectious diseases, but there could be other similar mutations that act upon other infectious disease; and there may be other mutations that are associated with other types of chronic diseases. He mentioned both prostate and breast cancers.

HUGE is not an exaggeration. And look at the ramifications ... if lifespans are extended, the fiscal impact will be one impact. Medicare may avoid large expenses by keeping people healthier, but SS would have to deal with people livingmore years; and pension plans; and welfare programs as well. If the Chinese live longer, their population growth will be hard to control.
True, but if you ever watched someone rot away from cancer at a far too young age with NO cure, you would wish for something better.

stan b

Gerry Clinchy
11-15-2011, 06:43 AM
Absolutely, Stan.