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Thread: Ivomec warning

  1. #11
    Senior Member yellow machine's Avatar
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    Quote Originally Posted by Mary Lynn Metras View Post
    HEARTGARDŽ Plus (ivermectin/pyrantel)
    contains Ivermectin so what would be the difference. I agree with Dave need to have stats on what you are saying. I believe I have heard my vet say it is an issue of when the medication is given. Sometimes people skip doses and your dog could get infected then. It is also a good idea to make sure if you use Ivermection it is stored correctly and you give the correct dosage as calculated by your vet. Always check with your vet!JMHO
    Stored in the house under normal house temps is what I have been told to do by the supplier. Is this correct?
    A cold nose feels good on a hot day.....
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  2. #12
    Senior Member suepuff's Avatar
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    Yes please Dr Ed.
    Sue Puffenbarger
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  3. #13
    Senior Member Mary Lynn Metras's Avatar
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    Quote Originally Posted by yellow machine View Post
    Stored in the house under normal house temps is what I have been told to do by the supplier. Is this correct?
    I believe light affects the contents.
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  4. #14
    Senior Member Mary Lynn Metras's Avatar
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    Quote Originally Posted by EdA View Post
    I would be happy to supply a synopsis of the most recent data presented at the American Heartworm Society meeting in 2013 if anyone is interested, there is inaccurate information circulating in the dog world. It will be later today or tomorrow for those interested.
    I am interested and thank you.
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  5. #15
    Senior Member RJG's Avatar
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    I am interested and thank you Dr. Ed. I store mine in the fridge just in case - would like to know if it should be in a light blocking container. I use 1/10 of a cc per 10 lbs.
    Randall

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  6. #16
    Senior Member EdA's Avatar
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    Update on Canine Heartworm Prevention


    1. All currently available heartworm preventatives are members of the same group known as macrocyclic lactomes which includes ivermectin (Heartgard), milbemycin (Sentinel & Trifexsis) salemectin (Revolution), and moxidectin (Advantage Multi and Proheart 6 injection). There are 20+ compounds in that group.
    2. The macrocyclic lactomes kill the L3/L4 larvae in the tissue phase after inoculation of the larva by a mosquito bite.
    3. To be effective these products must be administered every 30 days, beyond 40 days some larva may not be affected, the exception being the injectable form of moxidectin (Proheart 6.)


    Heartworms Resistant to the class of drugs macrocyclic lactomes.


    In 2007 +\- the FDA received an abnormal number of reports of lack of efficacy hereafter referred to as LOE. The vast majority of these reports were from the Mississippi delta in TN, AK, MS, and LA. Subsequently there has been much speculation about the possibility of a resistant strain of the canine heartworm Dirofilaria Immitis in that region. A number of scientific studies have ensued, from those here is what we currently know.


    1. There does appear to be a genetically different strain of D. Immitis in those areas.
    2. The affected area does not appear to have expanded beyond that area.
    3. Of the reports of LOE an analysis of the medical records of those dogs reveals that 80% did not have sufficient product to administer to those dogs every 30 days.
    4. 99% of the dogs in the affected area are protected by currently available products.
    5. There is a genetically identifiable difference in the apparent D Immitis "resistant strain" however researchers currently think this strain is not as robust as the standard D. Immitis.
    6. Resistance to one member of that class equals resistance to all members since they all have the same mode of action.


    Current theory is that the resistant strain of D. Immitis may have resulted from the widespread use of the so called slow kill method of heartworm treatment in the indemic area.


    No kill shelter programs have moved thousands of potentially heartworm infected dogs into areas of the country which previously have not had heartworm disease. Many of these dogs come from the gulf coast and the Carribean where heartworm disease is prevalent.


    What can you do to protect your dog


    1. Give label approved heartworm preventatives every 30 days year round no matter where you live.
    2. If possible limit exposure to mosquitos with the use of screened or indoor kennels, mosquito traps, and/or mosquito repellents. Remember that mosquitos are most active from twilight until dawn.
    3. Perform annual heartworm tests for adult dogs. The sooner heartworm infections are treated the less likely for complications or long term pulmonary artery damage.


    Information is changing rapidly and what we know today could change tomorrow.


    For more information on canine heartworm disease visit http://heartwormsociety.org

  7. #17
    Senior Member jeff t.'s Avatar
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    Thanks Dr. Ed
    Jeff Telander
    Durham, NC

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  8. #18
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    Quote Originally Posted by Christine Maddox View Post
    I told the vet at Brittmoore the dosage that I had been giving and his reply was that it was more than adequate. (Julie) Yes, there is a resistance to Ivomec in this area.
    (Rboudet) Given the fact that it takes approximately 6 months from the time of the infected mosquito bite to become a mature heartworm, the timing of when I gave the last dosage is of no consequence. There is already detection in the bloodstream which means there has to be an adult present. (though I do give on the first of each month and she was tested on the 25th)
    (David) I am not a professional in this field so am not capable of publishing the exact data and was not offered such from the vet. I only wanted to pass along the word to others. I wish someone had passed it along to me.
    I meant the vet, not you. I appreciate you posting the info. I had a similar discussion with a drug rep last fall, who claimed that Heartguard was ineffective in the delta & that I should use his product. I asked for the data, he couldn't or wouldn't produce it, so I did a little investigation & found the data Ed posted. As it turned out the data didn't support his position but since Heartguard has been the supplier of choice for several years all the competitors were taking their shots. My question was much like several here who saw the inconsistency of saying Heartguard was ineffective but use my product that uses the same drug.
    David Didier, GA

  9. #19
    Senior Member HuntinDawg's Avatar
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    Thank you Dr. Ed.

    Here in Georgia there is no such thing as a time of day when mosquitoes are inactive. I have my yard sprayed for mosquitoes regularly during the prime season and it helps, but it is like shoveling crap against the tide.

    The way our dogs move around, especially working dogs, I am surprised that the area wherein the resistant strain is found has not expanded.
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  10. #20
    Senior Member EdA's Avatar
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    Quote Originally Posted by HuntinDawg View Post
    The way our dogs move around, especially working dogs, I am surprised that the area wherein the resistant strain is found has not expanded.
    It is somewhat surprising to those who have knowledge of vector borne diseases yet the area has remained fairly static so far which is the good news for most of us.

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