Yes please Dr Ed.
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I am interested and thank you Dr. Ed. I store mine in the fridge just in case - would like to know if it should be in a light blocking container. I use 1/10 of a cc per 10 lbs.
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Update on Canine Heartworm Prevention
1. All currently available heartworm preventatives are members of the same group known as macrocyclic lactomes which includes ivermectin (Heartgard), milbemycin (Sentinel & Trifexsis) salemectin (Revolution), and moxidectin (Advantage Multi and Proheart 6 injection). There are 20+ compounds in that group.
2. The macrocyclic lactomes kill the L3/L4 larvae in the tissue phase after inoculation of the larva by a mosquito bite.
3. To be effective these products must be administered every 30 days, beyond 40 days some larva may not be affected, the exception being the injectable form of moxidectin (Proheart 6.)
Heartworms Resistant to the class of drugs macrocyclic lactomes.
In 2007 +\- the FDA received an abnormal number of reports of lack of efficacy hereafter referred to as LOE. The vast majority of these reports were from the Mississippi delta in TN, AK, MS, and LA. Subsequently there has been much speculation about the possibility of a resistant strain of the canine heartworm Dirofilaria Immitis in that region. A number of scientific studies have ensued, from those here is what we currently know.
1. There does appear to be a genetically different strain of D. Immitis in those areas.
2. The affected area does not appear to have expanded beyond that area.
3. Of the reports of LOE an analysis of the medical records of those dogs reveals that 80% did not have sufficient product to administer to those dogs every 30 days.
4. 99% of the dogs in the affected area are protected by currently available products.
5. There is a genetically identifiable difference in the apparent D Immitis "resistant strain" however researchers currently think this strain is not as robust as the standard D. Immitis.
6. Resistance to one member of that class equals resistance to all members since they all have the same mode of action.
Current theory is that the resistant strain of D. Immitis may have resulted from the widespread use of the so called slow kill method of heartworm treatment in the indemic area.
No kill shelter programs have moved thousands of potentially heartworm infected dogs into areas of the country which previously have not had heartworm disease. Many of these dogs come from the gulf coast and the Carribean where heartworm disease is prevalent.
What can you do to protect your dog
1. Give label approved heartworm preventatives every 30 days year round no matter where you live.
2. If possible limit exposure to mosquitos with the use of screened or indoor kennels, mosquito traps, and/or mosquito repellents. Remember that mosquitos are most active from twilight until dawn.
3. Perform annual heartworm tests for adult dogs. The sooner heartworm infections are treated the less likely for complications or long term pulmonary artery damage.
Information is changing rapidly and what we know today could change tomorrow.
For more information on canine heartworm disease visit http://heartwormsociety.org
Thanks Dr. Ed
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David Didier, GA
Thank you Dr. Ed.
Here in Georgia there is no such thing as a time of day when mosquitoes are inactive. I have my yard sprayed for mosquitoes regularly during the prime season and it helps, but it is like shoveling crap against the tide.
The way our dogs move around, especially working dogs, I am surprised that the area wherein the resistant strain is found has not expanded.
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