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Thread: Genetic Marker Discovered For Degenerative Joint Disease, the german press release ba

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    Senior Member Aussie's Avatar
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    Default Genetic Marker Discovered For Degenerative Joint Disease, the german press release ba

    It appears that in Germany they have identified a genetic marker for the predisposition of degenerative joint disease.
    Here is the press release (in German)
    http://idw-online.de/pages/de/news253028

    Genetic marker for joint disease in dogs discovered
    Sonja of Brethorst, Press and Public Relations
    Foundation School of Veterinary Medicine Hanover

    31.03.2008

    TiHo researchers, research prior to meeting The Institute for animal breeding and genetics research of the Foundation School of Veterinary Medicine Hanover, under the direction of Prof. Dr. Ottmar Distl, it is together with the Association of German Shepherd dogs (SV), the Society for the Promotion kynologischer Research (GKF) and the Association for German Hundewesen (VDH) succeeded genetic markers to develop, with the German shepherd dogs in the assessment for Hüftgelenkdysplasie (HD)
    can be established. The Hüftgelenkdysplasie in dogs is the most important disease of the movement's institutions. It comes in all races, is at large and fast-growing but often breeds more pronounced. The hereditary disease results from an aberration of the hip joint and leads patients to severe pain during the movement.

    On Wednesday, 2 April 2008, from 9:45 am, the scientists presented their current research findings in the auditorium of the Institute of Pathology, Bünteweg 17 to a broad audience breeders and veterinarians.

    At the meeting, we invite you warmly.

    The elucidation of the molecular genetic disease at the same time serves as a model to show how it is possible diseases caused by the interaction of many genes and complex metabolic processes, with molecular genetic techniques to combat. Through the application of the new test procedure, it will be possible to selectively breed and thus inherited Hüftgelenkdysplasie back at the dog. In continuation to the researchers new insights into the origins of the disease and thus win approaches for the development of new therapeutic approaches and develop preventive measures.

    With no other animal we have such an extensive knowledge of physical features, behavioral characteristics and inherited diseases such as Small dog. About a hundred molecular genetic diseases have been explored. But it is only about individual genes, complex disorders were at the dog has not yet been elucidated with molecular methods. Even when people are genetically complex diseases, such as joints, cardiovascular diseases and cancer, difficult to process, the dog can be used as a model for diseases in humans. That speaks well that dogs is a very similar environment with the people and therefore share similar environmental conditions and living conditions are like humans.

    The President of the Foundation of Veterinary Medicine Hannover Dr. Gerhard Greif, together with the President of the Association of German Shepherd dogs Wolfgang Henke, Christofer Habig, president of the Association of the German dog care, open the event.

    For further information, please contact:
    Prof. Dr. Ottmar Distl
    Institute for animal breeding and genetics research
    Tel (05 11) 9 53 88 75
    E-mail: ottmar.distl@tiho-hannover.de

    URL of this press release: http://idw-online.de/pages/de/news253028

    Characteristics of this press release:
    Biology and Biotechnology, Medicine and Health Sciences
    Transregional

    __________________________________________________ ___________________________
    Received: 11 May 2007 Accepted: 25 September 2007 Published online: 20 November 2007
    Abstract Canine hip dysplasia (CHD) is a common hereditary developmental disease of the coxofemoral joints. CHD is characterized by subluxation of the femoral head and deformation of the acetabulum leading to a painful osteoarthrosis.
    Analyses of mode of inheritance have shown the involvement of a major gene in expression of CHD in German Shepherd dogs. Thus, a whole genome scan for quantitative trait loci (QTL) was performed in German Shepherd dogs.
    For this purpose 11 paternal half-sib families, including a total of 459 purebred German Shepherd dogs with sires, dams, and offspring, were genotyped for 261 microsatellites.
    These markers were equidistantly distributed over all 38 autosomes and the X chromosome with an average marker distance of 11.7 cM. The mean observed heterozygosity of the marker set was 50%. The CHD status for the dogs was scored according to the official rules of the Fédération Cynologique Internationale.
    At the genome-wide level of significance at p < 0.05, QTL for CHD were located on nine different canine chromosomes: 1, 3, 4, 8, 9, 16, 19, 26, and 33. The minimal QTL regions containing the CHD genes spanned on average 5 Mb with a range between 1 and 8.2 Mb. Chromosome-wide level of significance at p < 0.05 was found for QTL on 19 chromosomes.
    Further analyses can now be performed to refine these map positions of QTL already identified in German Shepherd dogs.
    Electronic supplementary material The online version of this article (doi: 10.1007/s00335-007-9071-z) contains supplementary material, which is available to authorized users.
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    Senior Member Aussie's Avatar
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    Sorry for the poor translation.
    Field trial labradors, the wind beneath my wings,

    sometimes poop under my boots.

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    Did you translate it?
    mrgd

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    Senior Member Sissi's Avatar
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    I've heard about it to, only some days ago, It was developed for German Shepards and there seems to be more research work necessary to use it for other breeds.
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    Senior Member Judy Chute's Avatar
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    ..would think there might be more posts to this news?

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    Senior Member Howard N's Avatar
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    If I knew what the news was I might post about it. The machine translation left much to be desired.
    Howard Niemi

    You really gotta be careful about how high a pedestal you put your method, your accomplishments, your dog on. There's usually someone who's done more, somewhere. And they may have used a different method than you did! Chris Atkinson 2013

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    Senior Member Sissi's Avatar
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    Ok I try to help with the translation. But I´m in no means an expert on this topic and I´m hoping for the help of my fellow germans here.

    The University of Hannover found genetic markers which describe the dispostion of German Shepards for HD.
    Up so far it is only for German Shepards, but it seems to be possible with further research to use it for other breeds and they will develope a genetic test, for HD.

    I think this is something really important for breeders. Although I don´t know the percentage of reliability
    By the way there is the link to another article about it
    http://www.derwesten.de/nachrichten/...05/detail.html
    Last edited by Sissi; 04-05-2008 at 12:19 PM.
    Ulrike
    owned by:
    Ch Caballus L'Tiempo WT,BH
    Ch Engadin's Star Agamy WT,JEPs
    Ch.Lucky Curl's Aphrodite WT, BHP, APD/A
    Lucky Curl´s Beatrix JEPs, WCX

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    Senior Member achiro's Avatar
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    IS this for HD or DJD? Because they are two very different things.
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    Senior Member Sissi's Avatar
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    Quote Originally Posted by achiro View Post
    IS this for HD or DJD? Because they are two very different things.
    As far as I know, they are talking about HD.
    Ulrike
    owned by:
    Ch Caballus L'Tiempo WT,BH
    Ch Engadin's Star Agamy WT,JEPs
    Ch.Lucky Curl's Aphrodite WT, BHP, APD/A
    Lucky Curl´s Beatrix JEPs, WCX

  10. #10
    Senior Member Aussie's Avatar
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    Quote Originally Posted by MRGD View Post
    Did you translate it?
    No...copied directly from initial informer.

    Sissi, any further word.

    I have passed it to a few Australian veterinary surgeons, who have a special interest on the subject.

    Unfortunately I have been away training, so have to return a couple of phone calls. One vet managed to locate me in a suspect cell phone area, and mentioned this study patterns itself on a study by Gordon Lark from Utah.

    Anybody else????
    Field trial labradors, the wind beneath my wings,

    sometimes poop under my boots.

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