It appears that in Germany they have identified a genetic marker for the predisposition of degenerative joint disease.
Here is the press release (in German)
Genetic marker for joint disease in dogs discovered
Sonja of Brethorst, Press and Public Relations
Foundation School of Veterinary Medicine Hanover
TiHo researchers, research prior to meeting The Institute for animal breeding and genetics research of the Foundation School of Veterinary Medicine Hanover, under the direction of Prof. Dr. Ottmar Distl, it is together with the Association of German Shepherd dogs (SV), the Society for the Promotion kynologischer Research (GKF) and the Association for German Hundewesen (VDH) succeeded genetic markers to develop, with the German shepherd dogs in the assessment for Hüftgelenkdysplasie (HD)
can be established. The Hüftgelenkdysplasie in dogs is the most important disease of the movement's institutions. It comes in all races, is at large and fast-growing but often breeds more pronounced. The hereditary disease results from an aberration of the hip joint and leads patients to severe pain during the movement.
On Wednesday, 2 April 2008, from 9:45 am, the scientists presented their current research findings in the auditorium of the Institute of Pathology, Bünteweg 17 to a broad audience breeders and veterinarians.
At the meeting, we invite you warmly.
The elucidation of the molecular genetic disease at the same time serves as a model to show how it is possible diseases caused by the interaction of many genes and complex metabolic processes, with molecular genetic techniques to combat. Through the application of the new test procedure, it will be possible to selectively breed and thus inherited Hüftgelenkdysplasie back at the dog. In continuation to the researchers new insights into the origins of the disease and thus win approaches for the development of new therapeutic approaches and develop preventive measures.
With no other animal we have such an extensive knowledge of physical features, behavioral characteristics and inherited diseases such as Small dog. About a hundred molecular genetic diseases have been explored. But it is only about individual genes, complex disorders were at the dog has not yet been elucidated with molecular methods. Even when people are genetically complex diseases, such as joints, cardiovascular diseases and cancer, difficult to process, the dog can be used as a model for diseases in humans. That speaks well that dogs is a very similar environment with the people and therefore share similar environmental conditions and living conditions are like humans.
The President of the Foundation of Veterinary Medicine Hannover Dr. Gerhard Greif, together with the President of the Association of German Shepherd dogs Wolfgang Henke, Christofer Habig, president of the Association of the German dog care, open the event.
For further information, please contact:
Prof. Dr. Ottmar Distl
Institute for animal breeding and genetics research
Tel (05 11) 9 53 88 75
URL of this press release: http://idw-online.de/pages/de/news253028
Characteristics of this press release:
Biology and Biotechnology, Medicine and Health Sciences
Received: 11 May 2007 Accepted: 25 September 2007 Published online: 20 November 2007
Abstract Canine hip dysplasia (CHD) is a common hereditary developmental disease of the coxofemoral joints. CHD is characterized by subluxation of the femoral head and deformation of the acetabulum leading to a painful osteoarthrosis.
Analyses of mode of inheritance have shown the involvement of a major gene in expression of CHD in German Shepherd dogs. Thus, a whole genome scan for quantitative trait loci (QTL) was performed in German Shepherd dogs.
For this purpose 11 paternal half-sib families, including a total of 459 purebred German Shepherd dogs with sires, dams, and offspring, were genotyped for 261 microsatellites.
These markers were equidistantly distributed over all 38 autosomes and the X chromosome with an average marker distance of 11.7 cM. The mean observed heterozygosity of the marker set was 50%. The CHD status for the dogs was scored according to the official rules of the Fédération Cynologique Internationale.
At the genome-wide level of significance at p < 0.05, QTL for CHD were located on nine different canine chromosomes: 1, 3, 4, 8, 9, 16, 19, 26, and 33. The minimal QTL regions containing the CHD genes spanned on average 5 Mb with a range between 1 and 8.2 Mb. Chromosome-wide level of significance at p < 0.05 was found for QTL on 19 chromosomes.
Further analyses can now be performed to refine these map positions of QTL already identified in German Shepherd dogs.
Electronic supplementary material The online version of this article (doi: 10.1007/s00335-007-9071-z) contains supplementary material, which is available to authorized users.