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Thread: 2008 RABIES--Report on Adverse Vaccine Reactions in Dogs & Vaccine info

  1. #231
    Senior Member Kris L. Christine's Avatar
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    Rabies Vaccine -- 3 yr Vaccine Relabeled as 1 yr

    The USDA allows vaccine manufacturers to relabel their 3 year rabies vaccines as 1 year products. This link http://www.calmanimalcare.com/vaccine.htm , you will be taken to the Calm Animal Care website, which has posted Colorado State University's Small Animal Vaccination Protocol for its veterinary teaching hospital, which states:"Even with rabies vaccines, the label may be misleading in that a three year duration of immunity product may also be labeled and sold as a one year duration of immunity product."

    "In the case of Defensor 1 and Defensor 3 vaccines made by Pfizer, testing is the only difference between the products. 'The formulations are the same, but regulatory requirements for the one- and three-year vaccines are different, requiring distinct and separate studies for each label,' said Pfizer spokesman Richard Chambers."
    States Consider Controlling Rabies Vaccination Intervals, by Edie Lau The Veterinary Information Network News Service 8/12/11 http://news.vin.com/VINNews.aspx?articleId=19501

    According to Dr. Ronald Schultz of the University of Wisconsin School of Veterinary Medicine, "There is no benefit from annual rabies vaccination and most one year rabies products are similar or identical to the 3-year products with regard to duration of immunity and effectiveness. However, if they are 1 year rabies vaccines, they must be legally given annually!" from What Everyone Needs to Know about Canine Vaccines
    http://www.puliclub.org/CHF/AKC2007C...20Vaccines.htm

    In an April 1, 2008 DVM360 article entitled, Canine Vaccine Update (Proceedings) http://veterinarycalendar.dvm360.com.../detail/562405 by Dr. Craig Datz states that, "..some brands of rabies vaccine are identical whether labeled as 1- or 3-year..."

    2006 Canine & Feline Vaccination Guidelines, A Forum on Issues and Controversies by Dr. Richard B. Ford, DVM, Professor of Medicine, North Carolina State University College of Veterinary Medicine http://www.hcvma.org/notes/SpeakerNotesRichardFord.pdf Table 2 on Page 4 states: Vaccine Type: Rabies, 1-year: Minimum Duration of Immunity: 3 Years (must be administered annually)
    Kris L. Christine
    Founder, Co-Trustee
    THE RABIES CHALLENGE FUND
    www.RabiesChallengeFund.org

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    Saving Lives With Antibody Titer Tests http://www.maddiesfund.org/Resource_Library/Saving_Lives_With_Antibody_Titer_Tests.html w/Dr. Ronald Schultz. Free webcast Thursday, September 8, 2011, at 9 PM Eastern/8 PM Central/7 PM Mountain/6 PM Pacific.
    Kris L. Christine
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    THE RABIES CHALLENGE FUND
    www.RabiesChallengeFund.org

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    California Rabies Medical Exemption Signed into Law

    On Friday, October 7, 2011, California's Governor signed a rabies medical exemption into law, Molly's Bill (AB 258), , http://www.leginfo.ca.gov/pub/11-12/...chaptered.html . California is the 14th state to do so.

    Please copy & paste link into browser if it doesn't work by clicking on it.

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  4. #234
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    2011 American Animal Hospital Association's Canine Vaccine Guidelines https://www.aahanet.org/PublicDocume...Guidelines.pdf

    p. 3 "When compared with infectious (attenuated, avirulent, modified live, recombinant viral vectored) vaccines, noninfectious vaccines are more likely to produce local and systemic adverse reactions in some dogs."

    p.10 "Most noninfectious vaccines require at least two initial doses to immunize, regardless of the dog's age. The first does of a noninfectious vaccine generally primes the immune response and the second dose, which should be administered 2-6 weeks later, provides the protective immune response. Immunity typically develops approximately 7 days after the second dose. Therefore, the minimum time for onset of immunity is approximately 3 wk after administration of the first dose of a noninfectious vaccine"

    p. 12 "Because dogs older than 14-16 wk of age are not likely to have interfering levels of MDA [maternally derived antibodies], administration of a single initial dose of an infectious vaccine to an adult dog can be expected to induce a protective immune response. ..... MDA is the most common reason early vaccination fails to immunize."

    p. 12 "The onset of immunity after administration of a single dose of infectious core vaccine is approximately 4+3 days in the absence of MDA [maternally derived antibodies]."

    p.13 "Infectious core vaccines are not only highly effective, they also provide the longest DOI [duration of immunity], extending from 5 yr up to the life of the dog."

    p. 17 "Despite the confusion and controversy surrounding antibody testing, these serologic tests are useful for monitoring immunity to CDV, CPV-2, CAV-1, and RV. .....On completion of the puppy core vaccination series with the last dose given at 14-16 wk of age, a dog can be expected to have an antibody titer or positive test result, regardless of the serologic test performed, provided the serum sample is collected > 2 wk after the last dose of vaccine." (CDV=distemper, CPV-2 = parvovirus, CAV-1 hepatitis, RV= rabies)

    p. 18 "....the last dose of CDV and CPV should be administered at 14-16 wk of age. At this age, MDA should be at a level that will not block active immunity in most puppies (>98%) when a combination MLV vaccine is administered."

    p. 18 "In a study reported in 1997, dogs vaccinated with a product containing CDV (canine distemper virus) and then placed in an environment without CDV maintained antibody titers for at least 10 yr."

    p. 20 "...the list that follows includes categories of adverse reactions that have been attributed to vaccine administration.

    -Injection-site reactions: lumps (abscess, granuloma, seroma), pain, swelling, hair loss associated with ischemic vasculitis

    -Transient postvaccinal nonspecific illness: lethargy, anorexia, fever, regional lymphadenomegaly, soreness, abortion, encephalitis, polyneuritis, arthritis, seizures, behavioral changes, hair loss or color change at the injection site, respiratory disease

    -Allergic (hypersensitivity) and immune-mediated reactions:

    Type 1 (acute anaphylaxis): angiodema (especially the head), anaphylaxis (shock) and death

    Type 2 (cytolytic): immune-mediated hemolytic anemia, immune-mediated thrombocytopenia (suspected only; causality has not been confirmed)

    Type 3 (immune-complex): cutaneous ischemic vasculopathy associated with rabies vaccine, corneal edema ('blue-eye') associated with CAV-1 vaccine, immune-mediated disease.

    -Tumorigenesis: vaccine-associated sarcoma or other tumors

    Multisystemic infectious/inflammatory disorder of young Weimaraner dogs: may be genetically linked to both a poorly characterized immunodeficiency and to autoimmune disorders (e.g., hypothyroidism and hypertrophic osteodystrophy [HOD] that are detected shortly after vaccination

    -Vaccine-induced immunosuppression: associated with first or second dose of combination MLV vaccines containing CDV and CAV-1 or CAV-2 with or without other vaccines (e.g., CPV-2, CPI). Immunosuppression begins 3 days after vaccination and persists for 7-10 days. The suppression may be associated with increased susceptibility to other diseases.

    p. 21 "It is reasonable to avoid administration of any vaccine to patients with a history of systemic disease suspected to be associated with previous vaccination (e.g., immune-mediated hemolytic anemia, immune-mediated thrombocytopenia) or known to be caused by vaccine (vaccination-site cutaneous ischemic vasculitis after administration of rabies vaccine).

    p. 28 "As with pregnant dogs, veterinary medicine has advised against vaccination during illness, due to concerns about suboptimal protection, or worse, vaccine-induced illness."

    p. 29 "Manufacturers only recommend administration of vaccine to healthy dogs. Dogs receiving immunosuppressive chemotherapy should not be vaccinated. Doing so may result in a suboptimal immune response or may aggravate (reactivate) an immune-mediated illness."

    p.33 "Vaccine adverse events are significantly underreported in veterinary medicine."

    p. 34 "The vaccination protocol that includes the minimum number of vaccines yet still provides a reasonable opportunity to immunize the dog would be: a single dose of combined infectious (attenuated, avirulent, modified live, recombinant viral vectored) CDV, MLV CPV-2, with MLV CAV-2, administered at 16 wk of age or older, plus a rabies shot at the same time (but inoculated at a separate site on the body)."
    Kris L. Christine
    Founder, Co-Trustee
    THE RABIES CHALLENGE FUND
    www.RabiesChallengeFund.org

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    Analyzing New Vaccination Recommendations for Dogs, by Jan Rasmusen 11/15/11 http://www.dogs4dogs.com/blog/2011/1...on-guidelines/
    Kris L. Christine
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    MINNESOTA RABIES VACCINE SURVEY: 88.8% of veterinarians responding to a rabies survey from the Board of Veterinary Medicine indicated they give a 3 year rabies vaccine; yet 53.3% fail to give pet owners a corresponding 3 year rabies certificate (36.2% issue a 2 year certificate, 17.1% issue "other"). When asked if they inform clients when they put a different expiration date on the rabies certificate than that on the vaccine administered, 40.9% responded that they did not inform the client.

    A copy of this 12/14/11 report entitled "Rabies Vaccination Survey Report" may be requested from Dr. John King, Executive Director of the Minnesota Board of Veterinary Medicine (651) 201-2844 John.King@state.mn.us

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    The Minnesota Rabies Vaccination Survey Report has been posted on The Rabies Challenge Fund website: http://www.rabieschallengefund.org/i...ey_results.pdf
    Kris L. Christine
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    www.RabiesChallengeFund.org

  8. #238
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    MISSOURI Rabies Bill SB 566 ACTION ALERT

    (Please copy & paste link into your browser if it doesn't work by clicking on it.)

    MISSOURI: A rabies bill, SB 566 http://www.senate.mo.gov/12info/pdf-...ntro/SB566.pdf , has been introduced into the Missouri legislature and assigned to the Agriculture, Food Production & Outdoor Resources Committee. The Rabies Challenge Fund has written the letter below requesting that a medical exemption clause be inserted into this bill.

    What You Can Do

    If you are a Missouri resident, please contact the bill sponsor, Senator Dan Brown, and the Chair of the Agriculture Committee below & ask them to place a medical exemption clause into the language of the bill and to vote that the bill "ought to pass." Request that all of the Missouri pet owners you know to do the same.

    Senator Dan Brown (573) 751-5713 Dan.Brown@senate.mo.gov
    Senator Brian Munzlinger, Chair of the Agriculture Committee (573) 751-7985 Brian.Munzlinger@senate.mo.gov

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    January 14, 20012

    Senator Dan Brown
    Senator Brian Munzlinger

    RE: SB 566 Bill Requiring Dogs and Cats to be Vaccinated Against Rabies

    Greetings Senators Brown and Munzlinger:

    The Rabies Challenge Fund supports passage of the proposed language in SB 566 which would amend Section A, Chapter 322 RSMo, Subsection 322.035 (5) to require that dogs and cats be immunized against rabies in accordance with the current recommendations of the Centers for Disease Control’s (CDC) National Association of State Public Health Veterinarian’s (NASPHV) Rabies Compendium. Also in accordance with the Rabies Compendium, we strongly urge the Committee to insert a rabies medical exemption clause into the language of this bill.

    The Rabies Compendium directs that “All vaccinesmust be administered in accordance with the specifications of the product label or package insert,” and rabies vaccine labels specify that they are for healthy animals. In addition to limiting its rabies vaccine for use in healthy animals, Pfizer’s Defensor 3 label cautions that: “(a) protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised..”

    The states of Alabama, California, Colorado, Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, New York, Oregon, Vermont, Virginia, and Wisconsin all have medical exemption clauses for sick animals in their rabies immunization laws/regulations.

    Immunologically, the rabies vaccine is the most potent of the veterinary vaccines and associated with significant adverse reactions such as polyneuropathy “resulting in muscular atrophy, inhibition or interruption of neuronal control of tissue and organ function, incoordination, and weakness,”[1] auto-immune hemolytic anemia,[2] thrombocytopenia, anorexia, regional lymphadenomegaly, cutaneous ischemic vasculopathy;[3] autoimmune diseases affecting the thyroid, joints, blood, eyes, skin, kidney, liver, bowel and central nervous system; anaphylactic shock; aggression; seizures; epilepsy; and fibrosarcomas at injection sites are all linked to the rabies vaccine.[4] [5] It is medically unsound for this vaccine to be given to any animal deemed unhealthy by a veterinarian.

    A medical exemption clause would allow Missouri veterinarians to write waivers for animals whose medical conditions (such as those with cancer, kidney/liver failure, hemolytic anemia, thrombocytopenia, grand mal seizures, and chronic autoimmune disorders) would be exacerbated by rabies vaccination. The State of Maine inserted such an exemption for dogs into their 3 year rabies protocol, 7 M.R.S.A., Sec. 3922(3), which became effective in April 2005, and not one rabid dog has been reported in the nearly 7 years since.

    Maine’s exemption language is as follows:

    A. A letter of exemption from vaccination may be submitted for licensure, if a medical reason exists that precludes the vaccination of the dog. Qualifying letters must be in the form of a written statement, signed by a licensed veterinarian, that includes a description of the dog, and the medical reason that precludes vaccination. If the medical reason is temporary, the letter shall indicate a time of expiration of the exemption.

    B. A dog exempted under the provisions of paragraph 5 A, above, shall be considered unvaccinated, for the purposes of 10-144 C.M.R. Ch.251, Section 7(B)(1), (Rules Governing Rabies Management) in the case of said dog’s exposure to a confirmed or suspect rabid animal.


    Without a provision for medical exemptions in Section A, Chapter 322 RSMo, Missouri’s rabies immunization requirement would thrust an ethical quandary on veterinarians with seriously ill patients -- they must either violate their Veterinarian’s Oath and administer a rabies vaccine contrary to sound medical practice and against the vaccine manufacturer’s labeled instructions, or recommend their clients break the law by not immunizing their unhealthy pets against rabies. Being compelled by law to vaccinate sick dogs and cats against rabies in order for their clients to comply with the statute also puts Missouri’s veterinarians at risk of being held liable for any adverse reactions the animals may suffer after administering a vaccine inconsistently with the labeled directions. Owners of critically ill dogs may choose not to comply with the law rather than jeopardize the lives of their pets and then fail to license their dogs to avoid detection.

    On behalf of The Rabies Challenge Fund Charitable Trust and Missouri pet owners, we urge you to insert a medical exemption clause in Senate Bill 566 and to vote that the bill ought to pass. You may contact me at the number below if you would like any scientific data on the rabies vaccine or if you have any questions.

    Sincerely,


    Kris L. Christine
    Founder, Co-Trustee
    THE RABIES CHALLENGE FUND
    www.RabiesChallengeFund.org
    ledgespring@lincoln.midcoast.com

    cc: Dr. W. Jean Dodds
    Dr. Ronald Schultz
    Missouri Legislature & Agriculture Committee

    --------------------------------------------------------------------------------

    [1] Dodds, W. Jean Vaccination Protocols for Dogs Predisposed to Vaccine Reactions, The Journal of the American Animal Hospital Association, May/June 2001, Vol. 37, pp. 211-214

    [2] Duval D., Giger U.Vaccine-Associated Immune-Mediated Hemolytic Anemia in the Dog, Journal of Veterinary Internal Medicine 1996; 10:290-295

    [3] American Animal Hospital Association, 2011 Canine Vaccination Guidelines, p. 20

    [4] American Veterinary Medical Association (AVMA) Executive Board, April 2001, Principles of Vaccination, Journal of the American Veterinary Medical Association, Volume 219, No. 5, September 1, 2001.

    [5] Vascelleri, M. Fibrosarcomas at Presumed Sites of Injection in Dogs: Characteristics and Comparison with Non-vaccination Site Fibrosarcomas and Feline Post-vaccinal Fibrosarcomas; Journal of Veterinary Medicine, Series A August 2003, vol. 50, no. 6, pp. 286-291.
    Kris L. Christine
    Founder, Co-Trustee
    THE RABIES CHALLENGE FUND
    www.RabiesChallengeFund.org

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    MINNESOTA Board of Veterinary Medicine issues Rabies Vaccination Guidance Document 3/1/12 http://www.vetmed.state.mn.us/portal...ceDocument.pdf

    "rabies vaccination certificate should always comply with Minnesota Rule 1705.1146, including displaying the date of vaccination and the rabies vaccine labeled duration of immunity, even if the veterinarian recommends more frequent rabies vaccination"

    A major victory for Minnesota pet owners thanks to Jane Anderson & Chris Addington, who, with assistance from The Rabies Challenge Fund, have prompted the Minnesota Board of Veterinary Medicine to publish a rabies vaccination guidance document in order to get veterinarians to follow the recommendations of the CDC's Rabies Compendium, to issue rabies certificates accurately reflecting the duration of immunity on the vaccine label, to obtain documented informed consent if administering rabies vaccines off-label, and to have "credible, scientifically-based information....in the possession of the veterinarian and available for review" if the veterinarian chooses to adopt a booster protocol other than that recommended in the Compendium.

    The Rabies Vaccination Survey Report can be viewed here: http://www.rabieschallengefund.org/i...ey_results.pdf
    Kris L. Christine
    Founder, Co-Trustee
    THE RABIES CHALLENGE FUND
    www.RabiesChallengeFund.org

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    SCHULTZ SEMINAR NEW YORK: "The Vaccine Controversy" with Dr. Ronald Schultz, proceeds to benefit The Rabies Challenge Fund http://www.healthydogproject.org/Sit...g_Project.html hosted by The Healthy Dog Project on May 12, 2012 from 9:30-3:30 at the Fenimore Art Museum Auditorium in Cooperstown, New York.

    To register, contact Gloria at healthydogproject@me.com.

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    Kris L. Christine
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    THE RABIES CHALLENGE FUND
    www.RabiesChallengeFund.org

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