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Thread: Calico Lab May be a Chimera

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    Senior Member frontier's Avatar
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    Terrie Tomlinson
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    Senior Member Richard Finch's Avatar
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    Wow!


    Richard
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    Senior Member EdA's Avatar
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    This could make the silver Labrador obsolete, the commercial implications are enormous!

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    Senior Member PennyRetrievers's Avatar
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    That dog is awesome. I want one.
    "Somehow this creature has completed my manhood; somehow, I cannot explain why, a man ought to have a dog. A man ought to have six legs; those other four legs are part of him." -G.K. Chesterton

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    Senior Member Scott Adams's Avatar
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    Think of the visibility on blinds!
    This could be the way to go.
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    Senior Member firehouselabs's Avatar
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    They are actually called "Mosaic" Labs, and are generally rare. Usually result of improper cell division and is congenital, not genetic.
    domino2-s.jpgSpottyFace.jpgth.jpglabrador-pictus-2.jpgmosaic1.jpgSpottyBelly.jpgth.jpeg08KJQ.jpg

    • Alternatively, brindling in Labs may be the result of what geneticists call a mosaic. A mosaic indicates differences in the somatic tissue of heterozygotes that come about during mitotic division of somatic cells (recall from above that somatic cells are those that make-up the body). There are two possible ways by which an individual may become a mosaic. The first is called chromosome nondisjunction by which during division into daughter cells, one of the chromosomes fails to separate from its duplicated chromosome. As a result, one daughter cell receives an extra chromosome and the other receives an unpartnered-chromosome.
      The second way that a mosaic may be produced is called chromosome loss by which the chromosome containing the dominant allele gets left behind when the daughter cell's nucleus reconstitutes.
      In either situation described above, the daughter cells of these altered somatic cells will contain the same alterations. As a result, one will observe a mosaic or brindled pattern of normal color mixed with color produced by the altered somatic cells. This condition has been reported in a Lab showing mosaic black and yellow coat color. When this Lab was bred to other Labs of normal coat colors of black, chocolate, or yellow, it was determined that the variation in color was not due to a mutated E locus allele (like the "ebr" allele) because none of the offspring demonstrated this phenotype. Rather, this coat characteristic was attributed to a chromosomal alteration as described above.
      Therefore, the brindling phenotype rarely observed in Labs might be the result of a stable allele mutation (such as the "ebr" allele), or a random somatic chromosome mutation involving the E or B loci. To view an example of a mosaic occurring as a result of a random somatic chromosome mutation involving the E locus in the Labrador Retriever click here.
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    Senior Member DarrinGreene's Avatar
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    Great camo!
    Darrin Greene

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    Senior Member archer66's Avatar
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    I just bought two!! Ok..no I didn't....lol..

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    Senior Member afdahl's Avatar
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    There is a third way those mosaics could come about: a "back-mutation" of an e allele to E in a somatic cell early in development. Thanks to modern molecular genetics, we know that there are many possible errors in the copying of the e allele which would result in a mutant allele that produces black.

    Amy Dahl

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    Senior Member afdahl's Avatar
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    Great collection of pics, by the way.

    Amy Dahl

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