U Wisc Laryngeal Paralysis Study
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Thread: U Wisc Laryngeal Paralysis Study

  1. #1
    Senior Member Keith Stroyan's Avatar
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    Default U Wisc Laryngeal Paralysis Study

    A group at the University of Wisconsin Vet school is trying to determine the specific genetic mutations involved in Laryngeal Paralysis.

    They would like to collect saliva swabs from affected Labrador and Golden Retrievers and un-affected dogs 12 yr and older. (Not 11.5.)

    "
    Laryngeal paralysis is a disease that most commonly affects older (9-13+ years) Labrador Retrievers and Golden Retrievers, although other breeds can also be affected. The condition results in dogs having difficulty with breathing and mobility, which can become life-threatening.

    Laryngeal paralysis is most commonly the result of a generalized progressive neurologic disease, meaning that the condition affects many nerves in the body, not just the nerve associated with the larynx (voice box).

    Although we now know the condition is genetic (inherited), the specific gene mutation(s) is not known. This study focuses on understanding the genetic mutation(s) that results in laryngeal paralysis and the changes nerves undergo as a result of the disease.
    "
    https://www.vetmed.wisc.edu/lab/wp-c...yer-3-9-16.pdf

    My dog Zeke was affected at 12 yrs and is part of the study. Please consider helping with the study, especially with the healthy old dogs (who likely don't carry the mutation.)
    Last edited by Keith Stroyan; 07-13-2017 at 04:37 PM.

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    Junior Member Jkuhn63's Avatar
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    Thanks for sharing Keith,

    My beloved dog HRCH Luke L., RIP, was affected by this. I thought he was in heart failure at first, but was diagnosed with LP. By the time he was having symptoms, he was 13 and losing coordination (walking funny). It was soon obvious that he had some type of neurologic disease going on. He also had a temporary episode of vestibular syndrome (not sure if this was related to the laryngeal paralysis). I chose not to treat the laryngeal paralysis. He always loved riding in the back seat of my truck. Took him to McD's for his favorite bite of cheeseburger at 13.5 years of age before going to vet and putting him to rest..Vet was nice enough to come to my truck so he wouldn't have to leave he backseat.

  4. #3

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    I actually have my 13 year old FC Cosmo's Concerto Charlie son signed up for the CCL and LarPar study. They are letting my vet buddy do the x-rays locally and send them in. I figured he would be a good candidate since he has never had an issue with either. I know old Jack is just one dog but I hope if enough people sign up the experts can get us some real answers!

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    Senior Member Andy Carlson's Avatar
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    I have passed the link along to a friend who has a golden who was just diagnosed with LP. Hopefully she will participate!
    Andy

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    Senior Member suepuff's Avatar
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    I've got a 14 year old that can participate. I will put this in my clubs newsletter. Thanks!!!
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    My 13 yr old Tiger female would qualify and her sister is here locally, and I know the owners would let me sample her.
    Nate Baxter, DVM
    Clarksville, OH

  9. #7
    Senior Member labdoc's Avatar
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    Still taking enrollments, swabbed my affected 13 year-old today.
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    They are asking me for more information about two unaffected and one affected dog.
    Chuck

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    My 12 year old ylf just had the tie back surgery at Colorado State and participated in a clinical trial on gastroesophageal reflux and its possible relationship with aspiration pneumonia in dogs with lar par. She was monitored with a nasoesophageal probe for about 24 hours, then they performed the surgery. The website says they credit you $350 for participating in the study, but I received $500. Being a scientist myself, participating in this was a no-brainer for me.

    http://csu-cvmbs.colostate.edu/vth/v...cal-trial.aspx

  12. #10
    Senior Member Billie's Avatar
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    I emailed them, hoping we can participate and help in the study.
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