RetrieverTraining.Net - the RTF banner

Ivermec dosage

21K views 57 replies 29 participants last post by  Bob Glover  
#1 ·
I can't find Ivermec sold here in SW Iowa so I had my dad bring me some on his last visit. He brought me a bottle of Ivermec for "Grower and Feeder Pigs." It says its a 0.27% Solution. Any guess to how I should cut this?
 
#2 ·
#4 · (Edited)
According to the insert 1cc to 20 pounds but I would consult with your vet first.
Whoa! I am NOT a vet, but:
WAY TOO HIGH is my guess.

This adivce:
I also use 1%.

.1cc per 20 lbs on the 1st and 15th of the month. Get a diabetic syringe that measures in .10 cc (ml) increments

Some people dose .1 per 10 lbs once a month
is more like it for NON-herding breeds. Likely would kill your Border Collie...

Careful.
 
#6 ·
I live in south Louisiana in mosquito heaven and dose at 0.1cc per 10 lb and do give a touch more about 0.1cc to 0.3cc per dosing once monthly. Have never had a dog test positive in over 15 years. I don't use name brand normally, last I purchased Ivomax 1%.I know dogs can tolerate higher doses as this is a treatment used in mange at extreme doses.I am a pharmacist by trade.
 
#7 ·
The following is repeated from a vet's post on another forum:

Ivomec as a Heartworm Preventative

Ivomec (Do not use Ivomec Plus) is an injectable commercial cattle deworming product that can be used as heartworm preventative for dogs. We recommend this product to some of the clients in our practice who have large breeding operations or kennels as it is much more affordable and practical for those types of owners.

It can be given orally at a dose of 1 ml per 110 lbs and must be given once a month. At this dose it will control hookworms, roundworms, whipworms, ear mites, sarcoptic mange mites and will prevent heartworms also. DO NOT GIVE THIS PRODUCT TO A COLLIE OR SHELTIE OR ANY DOG WHICH IS A MIXED BREED DOG COMPRISED OF ONE OF THESE BREEDS.

It contains Ivermectin as its active ingredient which is also the same active ingredient that is in Heartguard Plus. Heartguard Plus contains Ivermectin and Pyrantel. Ivermectin is the ingredient which prevents heartworms and Pyrantel controls roundworms and hookworms. The dose of ivermectin in Heartguard Plus is much lower than the one listed above because this product is safe to give to all breeds of dogs. IVOMEC IS NOT!

Personally I recommend diluting the Ivomec with Propylene Glycol. The reason for this is that if you don't it is an extremely small dose and it can be difficult to make sure the dog gets the entire dose when dealing with such small amounts. For example a 55 lb dog would only get 1/2 ml. That is a small dose and leaves very little margin for error. Ivermectin is very bitter and dogs don't like it and salivate quite a bit.

The dilution ratio that we use is as follows: 1 ml of Ivermectin to 4 ml of Propylene glycol. If mixed at this ratio, the dose is 1 ml per 20 lbs of body weight given orally once a month.

In my practice we mix 20 ml of Ivermectin with 80 ml of Propylene Glycol to make a 100 ml bottle. If mixed at this ratio, the dose is still 1 ml per 20 lbs of body weight given orally once a month.

Be sure that all dogs put on the Ivomec are heartworm negative prior to starting its use. Because the dosage of Ivermectin is much higher than the one in Heartguard Plus this is very important. Also it is still a very good idea to have your dogs tested for heartworms at least once a year when using Ivomec as a heartworm preventative.

I realize that many will question as to why I would post this kind of information but it is quite simple. I realize that heartworm preventatives can be expensive for some people and for owners of kennels or large breeding facilities it can be a tremendous expense. Personally I would rather give them an option to use a product that I know will be effective rather than see them not use one at all. As I have stated above I do not really recommend this for owners who have only one or two dogs because I do not believe the savings to be that significant in that situation and I think the commercially prepared product is much better for them because of its convenience.
 
#50 ·
I realize this is a copy paste from another forum and this conversation is several years old, but I just received my new Ivermax and with every new shipment I ask for the off label recipe for heartworm, in case it's been revised or updated in any way. That being said what I was given varies a great deal from what the Vet is suggesting........

My instructions (as per the Ivermax distributor I order through) to dilute are: .5cc Ivermax (Ivermectin 1%) : 30cc Propylene Glycol
and instructions for dosage are: 1cc/20#

Interested in any thoughts on this, thanks in advance for your time! Gonna be a beautiful day to be outside with Retrievers here in PA! I hope you all are enjoying a beautiful day too!!
 
#8 ·
You have to be careful with advice on dosage. Some people give a heartworm dose and some people give a deworming dose which is higher. Best to consult with your vet for your kind of dog and the concentration for only heartworm. I have been using the deworming dose for about 10 years, and the heartworm dose before that for 10 years.
 
#9 ·
forgive my ignorance on the subject, but can you explain a tad more? i would assume a "deworming" dose is to get rid of adult worms already present, so i dont understand why you would do it for so long. i realize its probably not 10 yrs on the same dog, but then that would mean you have multiple dogs with adult worms.

also, i have heard that with a light affliction from adult heartworms you can continue with the prevention dose, that will kill microfilaria and prevent additional adults, but the ones there already will stay but at least dont get any worse.
 
#10 ·
forgive my ignorance on the subject, but can you explain a tad more? i would assume a "deworming" dose is to get rid of adult worms already present, so i dont understand why you would do it for so long. i realize its probably not 10 yrs on the same dog, but then that would mean you have multiple dogs with adult worms.
Lots of people give the deworming dose (1cc per 110#), especially now with failure of the Heartguard. I dilute it as Ken says for puppies to be more accurate. All of my dogs open their mouths for the stuff and make faces, one even before she gets it. I have less problems with roundworms in pups by doing it this way also. The heartworm dose is = to what is in heartguard. Never had a positive heartworm case.
 
#11 ·
thanks. i want to start on this but i am very nervous about it.

Ken: you state you recommend the commercial product for 1 or 2 dog owners, but isnt the commercial product experiencing a lot of breakthrough cases? other than cost, isnt this a close 2nd for using ivermec over the commercial product(s)?

or do you feel the number of breakthrough cases is not statistically significant for 1 or 2 dog owners?
 
#12 ·
Nancy,

Just to be clear, when you say "deworming" dose, are you are referring to roundworms, hooks, etc.?

I would think you're NOT talking about adult heartworms, which would be dangerous to attempt to treat in this manner.

Dogs should be tested to affirm they're heartworm free before ivermectin administration.

KN
 
#14 ·
my older dog has chronic generalized demodex mange, and gets 1.2 ml of ivermectin per day, every day. The dose for heartworm prevention is about 1/3 of that, once a month.
There's a HUGE safety margin.
He has gotten as much as 2.2 ml per day when the mange was very active, but did have some nervous system side effects at that dose.
 
#18 ·
After following posts on Ivermectin for awhile here and on other forums, I started my Boykin on it last month.

My Veterinarian recommended 0.1 ml for the 30 lb dog. I didn't question him but assume he wants to use the lower dose only for heartworm preventative, rather than the "deworming" dose of 0.1 mg/10 lbs.

I've read elsewhere that although dogs can tolerate infrequent high doses, prolonged usage can affect the liver.

Maysport
 
#19 ·
I've read elsewhere that although dogs can tolerate infrequent high doses, prolonged usage can affect the liver.
Just an FYI, my own almost 13 yo just had a chem panel and he is normal and I have been using the highest dose for @ 10 years.
 
#20 ·
Were do you find the propylene Glycol? I have called all over.
 
#21 ·
You can order it online from any number of places for $18-$30 per gallon.

1% ivermectin solution = 10 mg/ml = 10,000 mcg/ml

heartworm preventative dose 6-12 mcg/kg, 1cc 1% ivermectin in 29 cc propylene glycol yields approx 333 mcg/ml so that 1cc of the mixture approximates the concentration in Heartgard tablets for large dogs (272 mcg)

PLEASE NOTE THE DIFFERENCE BETWEEN MILLIGRAMS (mg) AND MICROGRAMS (mcg)

one milligram = 1000 micrograms

for years people have used the anti-intestinal parasite dose of 100 mcg/lb monthly = 0.01cc per lb or 0.1 ml of 1% ivermectin per 10 lbs body weight as a single monthly dose for heartworm prevention and worming for hookworms and roundworms

this is off label use which I neither condone or recommend, I merely offer the pharmacological information available from various veterinary pharmaceutical drug handbooks

COLLIES, SHETLAND SHEEPDOGS, OLD ENGLISH SHEEPDOGS, BORDER COLLIES, AND OTHER HERDING BREEDS are highly sensitive to toxicity hence the low dosage label of Heartgard tablets that is safe for all breeds
 
#23 ·
Thank You for the info!!
 
#24 ·
My lab was prescribed Ivomec for mites/mange...once a week for eight weeks. Is this the same as the 1% Ivermectin sold at Fleet Farm and considerably cheaper? Shouldn't my other lab be treated too? Also, I give the once a month Interceptor for heartworms but isn't that over-doing it?
 
#25 · (Edited)
I've read this thread and have a science background (degree in Chemistry from UI). Given that...and in my opinion....there is advice in this thread that is totally off base and results in gross over-dosing. The power of the Internet is obvious......"say something often enough and it must be true".

1 ml of water = 1 CC of water
1 CC of water = 1 gram
0.1 ml of water = 0.1 gram
0.1 ml (CC) of a 1% Ivermectin solution = 0.001 grams of Ivermectin

1 gram = 1,000,000 microgram
0.001 gram = 1,000 microgram
a dose of Heartguard for 50-100 pound dog contains 273 micrograms of Ivermectin

note: Keep in mind there is another ingredient in Heartguard which has a synergistic impact on the overall dosage.

which basically "says"....using 0.1 cc of a 1% solution of swine Ivermectin is equivalent to giving a dog almost 3.7 times the correct dose. Using 1 ml (CC) of the 1% solution is delivering 37 times the correct dose......EACH month.

Now assuming I am just another Internet poster.....providing just my opinion.....don't you think it might be a good idea to avoid Internet "voting" to determine the truth?

note: My dogs get Interceptor tablets every month and are tested for heart worms & others every year.
 
#27 · (Edited)
You did get that there is a "difference" between the "heartworm dosage" and the regular worming dosage correct?

Heartworms (like in Heartguard) take a lot less to kill off (as a preventative) than other worms.

Which dosage are you referring to is "over dosing"??

Dr Ed posted .1 cc per 10 lbs for heartworm dosage. What are you referring to?

WRL
 
#26 ·
The routine dose for heartworms that simulates the dose in heartguard is different (much lower)than the deworming dose. I used the heartworm only dose for many years but was given the other higher dose for intestinal parasites by two different vets and I am comfortable with it after about 10 years. The dose for mites is even higher yet, but again, not for collies shelties and mixes of those breeds.
 
#30 ·
...which basically "says"....using 0.1 cc of a 1% solution of swine Ivermectin is equivalent to giving a dog almost 3.7 times the correct dose.
Define "correct" dose.

Down here in the lower Mississippi valley, we've had so many breakthroughs with HeartGuard, I'm dubious as to it's effectiveness at all (because I think the dosage is too low).

There are too many competitive dogs whose owners' are diligent in administering preventative that have come down with hw's to overlook that something is going on. You cannot possibly convince me that ht and ft dogs aren't administered preventative more diligently than the general public, yet we're still seeing breakthroughs.

I administer .1ml per 20 lbs twice a month.
 
#32 · (Edited)
I don't think much of Merial's "guarantee" and I don't see the point of relying on a company whose product doesn't work in the first place to remedy an infestation that's not prevented by said product. I will spare my dogs running that gauntlet.

This is a HUGE problem in my area. We're at the epicenter of the heartworm problem (Baton Rouge). Frankly, I don't know anyone locally who is in the FT/HT game that uses HeartGuard anymore.
 
#33 · (Edited)
EdA said:
heartworm preventative dose 6-12 mcg/kg, 1cc 1% ivermectin in 29 cc propylene glycol yields approx 333 mcg/ml so that 1cc of the mixture approximates the concentration in Heartgard tablets for large dogs (272 mcg)............

for years people have used the anti-intestinal parasite dose of 100 mcg/lb monthly = 0.01cc per lb or 0.1 ml of 1% ivermectin per 10 lbs body weight as a single monthly dose for heartworm prevention and worming for hookworms and roundworms.........

this is off label use which I neither condone or recommend.......
I agree with these quotes (and the rest of the post).

Keith Stroyan said:
(For most people with one or two dogs the latest products from your vet are likely best. If you're going off label carefully, you likely need some VETERINARY sicence...
I did call my vet seeking "VETERINARY science" before before posting on this thread ;)

BS degree in Organic Chemistry regards, Jim
 
#35 ·
BS degree in Organic Chemistry regards, Jim
I also have a background in Chemistry, and what jumps out at me from this thread is possible uneven mixing of the Ivermectin solution with propylene glycol. Getting things evenly mixed usually takes a lot more mixing than people expect. I don't have experience with propylene glycol but expect it's viscous. It would take good, thorough mechanical mixing to distribute the drug evenly throughout the solution. If it's not evenly distributed, then the dose you draw out in 1 mL could be anything from almost nothing to almost all of the Ivomec you added.

Amy Dahl
 
#38 ·
If you are going to dilute it to the lower dose, you have to mix it or the concentration will be off, but you are putting the same diluent in that it is originally diluted with. In other words, you can't mix it with water or saline or a buffer.
 
#44 ·
My tallest horse (17 hands) hates it so he always gets wormed first because if he smells it on my hands he's a PITA, cranes his head so high I can't get it in his mouth and/or rears back and breaks lead ropes if I get the stepladder out. But the horses only get it 2x a year--and the dogs are easier to muscle around if they decide they'd rather not have it. And I do use the little teeny syringes and it's really hard to see the notches on them these days. Just wait, your day will come!