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U Wisc Laryngeal Paralysis Study

25K views 63 replies 25 participants last post by  dr_dog_guy  
#1 · (Edited)
A group at the University of Wisconsin Vet school is trying to determine the specific genetic mutations involved in Laryngeal Paralysis.

They would like to collect saliva swabs from affected Labrador and Golden Retrievers and un-affected dogs 12 yr and older. (Not 11.5.)

"
Laryngeal paralysis is a disease that most commonly affects older (9-13+ years) Labrador Retrievers and Golden Retrievers, although other breeds can also be affected. The condition results in dogs having difficulty with breathing and mobility, which can become life-threatening.

Laryngeal paralysis is most commonly the result of a generalized progressive neurologic disease, meaning that the condition affects many nerves in the body, not just the nerve associated with the larynx (voice box).

Although we now know the condition is genetic (inherited), the specific gene mutation(s) is not known. This study focuses on understanding the genetic mutation(s) that results in laryngeal paralysis and the changes nerves undergo as a result of the disease.
"
https://www.vetmed.wisc.edu/lab/wp-...b/wp-content/uploads/sites/9/2016/03/Laryngeal-Paralysis-study-flyer-3-9-16.pdf

My dog Zeke was affected at 12 yrs and is part of the study. Please consider helping with the study, especially with the healthy old dogs (who likely don't carry the mutation.)
 
#2 ·
Thanks for sharing Keith,

My beloved dog HRCH Luke L., RIP, was affected by this. I thought he was in heart failure at first, but was diagnosed with LP. By the time he was having symptoms, he was 13 and losing coordination (walking funny). It was soon obvious that he had some type of neurologic disease going on. He also had a temporary episode of vestibular syndrome (not sure if this was related to the laryngeal paralysis). I chose not to treat the laryngeal paralysis. He always loved riding in the back seat of my truck. Took him to McD's for his favorite bite of cheeseburger at 13.5 years of age before going to vet and putting him to rest..Vet was nice enough to come to my truck so he wouldn't have to leave he backseat.
 
#3 ·
I actually have my 13 year old FC Cosmo's Concerto Charlie son signed up for the CCL and LarPar study. They are letting my vet buddy do the x-rays locally and send them in. I figured he would be a good candidate since he has never had an issue with either. I know old Jack is just one dog but I hope if enough people sign up the experts can get us some real answers!
 
#4 ·
I have passed the link along to a friend who has a golden who was just diagnosed with LP. Hopefully she will participate!
 
#5 ·
I've got a 14 year old that can participate. I will put this in my clubs newsletter. Thanks!!!
 
#9 ·
My 12 year old ylf just had the tie back surgery at Colorado State and participated in a clinical trial on gastroesophageal reflux and its possible relationship with aspiration pneumonia in dogs with lar par. She was monitored with a nasoesophageal probe for about 24 hours, then they performed the surgery. The website says they credit you $350 for participating in the study, but I received $500. Being a scientist myself, participating in this was a no-brainer for me.

http://csu-cvmbs.colostate.edu/vth/...of-gastroesophageal-reflux-in-dogs-with-laryngeal-paralysis-clinical-trial.aspx
 
#10 ·
I emailed them, hoping we can participate and help in the study.
 
#21 ·
Its so awful. Carson is a field champion. He started running HT after he retired. But now he's hoarse like you say, pants heavily after a 10-yard retrieve (which we don't do anymore), and is also steadily losing mobility. He now stumbles around regularly. Going up and down the stairs - well, we'll see how long he can keep staying in my downstairs room. To see this deterioration in such an athlete, in what is the canine equivalent of an Olympic medalist, breaks my heart. I'm told its linked to neurological deterioration that starts in the hindquarters, slowly moving forward. I've seen something similar in my Goldens, both with and without the LP. Carson is the worst. I discovered its not just the gold dogs, this black one is so bad.
 
#22 ·
I didn't know until today that LP also affected the muscles in the hind legs. I just thought my girl was just getting old. I am going to put her on weight mgt ProPlan and see if that helps some. She is not overly over weight and Vet didn't say anything about her weight but I think it might help. I did contact the research clinic and they are sending me a kit to get started. I really do not like the idea of the surgery. Too much chance of aspiration and do not want to do that to my girl. She loves to eat and I put water in her food to slow her down, so I do not want to take a chance of her having the food or water go down the wrong pipe.
 
#25 ·
Several years ago I watched my 12 yr old dog die from LP. He went for walk and began gasping for air. By the time I got him 8 miles to vet his tongue was blue and was letting out a “yip” about every 10’seconds. Temp was past the 110 mark on thermometer. Put him to sleep immediately. He really wasn’t that bad before this attack. A terrible way for him to die and a terrible thing for wife and I to watch.