What is it, what does it stand for, and how to you go about getting a dog tested for it?
dmac1175
Centronuclear Myopathy, like human muscular dystrophy. It is a muscle wasting disease. Here is the link to info:
http://labradorcnm.com/
This site provides the test kit you need to test your dog. It is only $55 and just requires a sample of cheek cells.
Meredith
http://labradorcnm.com/
This site provides the test kit you need to test your dog. It is only $55 and just requires a sample of cheek cells.
Meredith
DDC is here in the U.S. http://www.vetdnacenter.com/
They send a free cheek swab kit.
CNM is $58, you can add EIC at the same time for $20.
Results emailed in a few days.
They send a free cheek swab kit.
CNM is $58, you can add EIC at the same time for $20.
Results emailed in a few days.
CNM was identified by Dr. Laurent Tiret and his team. There is a white list on the web site www.labradorcnm.com where clear dogs are posted.
Results from other laboratories are not posted on their white list due to a lack of reliability of results. We have not approved any other locations. Nor have we approved nor discussed the ones that are listed by OFA for CNM in addition to Alfort. We have no idea how those laboratories were chosen. OFA specializes in orthopedic clearances. They have never asked us about any CNM DNA approvals of other laboratories.
We are currently working with several stud owners, on both sides of Atlantic, whose dogs had been mistakenly identified as clear by other laboratories when they were carriers. There is no way of an owner initially identifying whether a result is valid until a few generations later affected or carrier pups are found. There are ways of confirming reliability but most owners do not have those capabilities.
Parentage is quite different in process of identification as opposed to finding an specific disease mutation. Laboratories have been doing parentage for many years for both humans and canines.
Perhaps sometimes saving a few dollars is not as important as accuracy. Just because some results turn out as expected does not mean that all do. Verifying accuracy of results is too long a topic to discuss here.
All money from CNM testing at Alfort goes directly into more research. None of the staff receive any extra money for their time on the project --- including myself. Their main concern is to benefit canines and humans.
Please send questions to me privately at cnminfo@centurytel.net
Happy Retrieving
Marilyn
Marilyn J Fender , PhD, CNM Project Global Communications.
cnminfo@centurytel.net www.labradorcnm.com
Results from other laboratories are not posted on their white list due to a lack of reliability of results. We have not approved any other locations. Nor have we approved nor discussed the ones that are listed by OFA for CNM in addition to Alfort. We have no idea how those laboratories were chosen. OFA specializes in orthopedic clearances. They have never asked us about any CNM DNA approvals of other laboratories.
We are currently working with several stud owners, on both sides of Atlantic, whose dogs had been mistakenly identified as clear by other laboratories when they were carriers. There is no way of an owner initially identifying whether a result is valid until a few generations later affected or carrier pups are found. There are ways of confirming reliability but most owners do not have those capabilities.
Parentage is quite different in process of identification as opposed to finding an specific disease mutation. Laboratories have been doing parentage for many years for both humans and canines.
Perhaps sometimes saving a few dollars is not as important as accuracy. Just because some results turn out as expected does not mean that all do. Verifying accuracy of results is too long a topic to discuss here.
All money from CNM testing at Alfort goes directly into more research. None of the staff receive any extra money for their time on the project --- including myself. Their main concern is to benefit canines and humans.
Please send questions to me privately at cnminfo@centurytel.net
Happy Retrieving
Marilyn
Marilyn J Fender , PhD, CNM Project Global Communications.
cnminfo@centurytel.net www.labradorcnm.com
DDC guarantees accuracy and turnaround and is recognized as the gold standard for DNA testing in the US and worldwide... http://www.dnacenter.com/dna-testing-laboratory.html
The reason why these laboratories are chosen by OFA is due to their long standing reputation for quality and service. DDC chooses to pass on savings to the customer and then the customer can choose to donate that savings back into DNA research if they so desire.
Most of the DNA inherited disease research is actually subsidized with private money from breeders and foundations who wish to further the cause through donations of money and samples. The role of the university is normally to teach students funded by tuition and again, private donations and some do perform research funded by these grants and with labor provided by graduate students. When a specific genetic mutation is discovered, the discovering researchers get the benefit of taking credit for the discovery through the publication of a scientific paper but generally, unless the institution has been granted worldwide patents, there is not really an "approval" process that takes place.
The reason other lab results are not included on the "white" list is, simply put, it's not their list. Rather, like a club, the owner of the list gets to choose who gets in and since allowing competitors results on the list might be counterproductive to a revenue source, it doesn't make much sense.
The reason why these laboratories are chosen by OFA is due to their long standing reputation for quality and service. DDC chooses to pass on savings to the customer and then the customer can choose to donate that savings back into DNA research if they so desire.
Most of the DNA inherited disease research is actually subsidized with private money from breeders and foundations who wish to further the cause through donations of money and samples. The role of the university is normally to teach students funded by tuition and again, private donations and some do perform research funded by these grants and with labor provided by graduate students. When a specific genetic mutation is discovered, the discovering researchers get the benefit of taking credit for the discovery through the publication of a scientific paper but generally, unless the institution has been granted worldwide patents, there is not really an "approval" process that takes place.
The reason other lab results are not included on the "white" list is, simply put, it's not their list. Rather, like a club, the owner of the list gets to choose who gets in and since allowing competitors results on the list might be counterproductive to a revenue source, it doesn't make much sense.
Yes DDC isn't bad they got it 100% right on one of my friends dogs and only made the one mistake on the other one of his dogs, so they had that dog 50% right. It was just a simple mistake of switching the two dogs results according to DDC.
I am still not sure who the Phd's are at DDC? I know who they are at Alfort and University of Minnisota but can't get that info for DDC.
I am still not sure who the Phd's are at DDC? I know who they are at Alfort and University of Minnisota but can't get that info for DDC.
Joe
Some clarification:
The reason that other laboratories do not have their results put on the Alfort white list is that we have found all too many errors in their results. We are working with several breeders, on both sides of the Atlantic, who had other laboratories identify dogs as clear when they were carriers. It is to the benefit of breeders to be able to look at a highly secure list that they can count on as accurate.
Those "for profit" laboratories that "say" they guarantee results won't know there is an error in the results until a generation or more later when carrier and affected pups show up.
So what do they mean by "guarantee" ??? Does it just mean that they will refund the payment a few years later ??
Carrier pups have no characteristics ---- so it all looks initially good to the owner. Then the owner typically contacts us when they find a problem in future litters -- not the "for profit" location who did the test. We explain it was the administration of the test and not the test. We are working with several now to try and rescue their situation where their mis-identified dog has spread the disease to many litters. The same thing is happening with other diseases, not just CNM.
Many think that the other laboratories are related to us. We get questions all the time from people who tested in other places and assume it is our branch laboratory. They have no idea it is simply a "for profit" location who we might not even know exists.
All the money from CNM testing is put directly into research. No one makes any money from it --- including myself. The scientific teams are much more concerned with research than money. There have been several other disease mutations identified in various breeds as a result. Every test sent to Alfort supports future research and is not personal profit.
You are not the person who decides what the role of a college is or is not. It is just your opinion that is convenient for you since you are for some reason really trying to sell a "for profit" laboratory to folks on RTF.
It is always better to test with the laboratory that identified the mutation (such as EIC or Optigen have identified disease mutations) as they know the most about the disease. The "for profits" often have not even see a dog with the disease they are testing for. I have noted that some of the "for profit" locations offer disease tests for breeds that do not carry that disease or the coat color tests offered.
It is apparent you feel committed to a certain "for profit" location. It is fine that you express your opinion. It is what discussion lines are for. I know you are trying to be helpful to RTF readers.
Best regards,
Marilyn
Marilyn J Fender, PhD
CNM Global Communications Coordinator
Some clarification:
The reason that other laboratories do not have their results put on the Alfort white list is that we have found all too many errors in their results. We are working with several breeders, on both sides of the Atlantic, who had other laboratories identify dogs as clear when they were carriers. It is to the benefit of breeders to be able to look at a highly secure list that they can count on as accurate.
Those "for profit" laboratories that "say" they guarantee results won't know there is an error in the results until a generation or more later when carrier and affected pups show up.
So what do they mean by "guarantee" ??? Does it just mean that they will refund the payment a few years later ??
Carrier pups have no characteristics ---- so it all looks initially good to the owner. Then the owner typically contacts us when they find a problem in future litters -- not the "for profit" location who did the test. We explain it was the administration of the test and not the test. We are working with several now to try and rescue their situation where their mis-identified dog has spread the disease to many litters. The same thing is happening with other diseases, not just CNM.
Many think that the other laboratories are related to us. We get questions all the time from people who tested in other places and assume it is our branch laboratory. They have no idea it is simply a "for profit" location who we might not even know exists.
All the money from CNM testing is put directly into research. No one makes any money from it --- including myself. The scientific teams are much more concerned with research than money. There have been several other disease mutations identified in various breeds as a result. Every test sent to Alfort supports future research and is not personal profit.
You are not the person who decides what the role of a college is or is not. It is just your opinion that is convenient for you since you are for some reason really trying to sell a "for profit" laboratory to folks on RTF.
It is always better to test with the laboratory that identified the mutation (such as EIC or Optigen have identified disease mutations) as they know the most about the disease. The "for profits" often have not even see a dog with the disease they are testing for. I have noted that some of the "for profit" locations offer disease tests for breeds that do not carry that disease or the coat color tests offered.
It is apparent you feel committed to a certain "for profit" location. It is fine that you express your opinion. It is what discussion lines are for. I know you are trying to be helpful to RTF readers.
Best regards,
Marilyn
Marilyn J Fender, PhD
CNM Global Communications Coordinator
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